منابع مشابه
Progressive Multifocal Leukoencephalopathy in an Immunocompetent Patient?
A 69-year old man presents with a subacute history of worsening confusion, anxiety and abnormal gait. Brain MRI revealed an extensive non-enhancing signal abnormality of parieto-occipito-temporal white matter. CSF PCR was positive for JC virus, suggestive of progressive multifocal leukoencephalopathy (PML). Extensive workup for occult immunosuppression was negative. Although PML in an immunocom...
متن کاملProgressive multifocal leukoencephalopathy in an AIDS patient.
Progressive multifocal leukoencephalopathy (PML) is a demyelinating brain disease caused by Jamestown Canyon virus (JCV). This disease is an important cause of morbidity and mortality in acquired immunodeficiency syndrome (AIDS) patients. We report a 34-year-old man infected with HIV-1 who presented with frequent general tonic clonic seizure and left side weakness for 2 months. Clinical feature...
متن کاملAn animal model for progressive multifocal leukoencephalopathy.
JC virus (JCV) causes progressive multifocal leukoencephalopathy (PML), a demyelinating disease in humans. The disease, once considered fatal, is now managed with immune reconstitution therapy; however, surviving patients remain severely debilitated. Until now, there has been no animal model to study JCV in the brain, and research into treatment has relied on cell culture systems. In this issue...
متن کاملProgressive multifocal leukoencephalopathy in an immunocompetent patient
Progressive multifocal leukoencephalopathy in an immunocompetent patient Nicolien M. van der Kolk, Peer Arts, Ingeborg W. M. van Uden, Alexander Hoischen, Frank L. van de Veerdonk, Mihai G. Netea & Brigit A. de Jong Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands Department of Genetics, Radboud University Medical Center, Nijmegen, The Netherlands Department...
متن کاملProgressive Multifocal Leukoencephalopathy.
Progressive multifocal leukoencephalopathy is a subacute demyelinating disease that occurs in patients with defects in cell-mediated immunity, including those with AIDS and lymphoproliferative disorders. It is caused by reactivation of JC virus (JCV), which infects 70% to 90% of the population by adulthood, but remains latent in normal hosts. Once reactivated, JCV infects oligodendrocytes and a...
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ژورنال
عنوان ژورنال: Clinical Case Reports and Reviews
سال: 2021
ISSN: 2059-0393
DOI: 10.15761/ccrr.1000497